College Soccer News issues its initial rankings of the top fifty players in the high school class of 2021. The rankings will be revised periodically to reflect changes in the standing of the players and their destination.
| Rank | Player | Club Team | Hometown | Position | School |
| 1 | Gio Reyna | Borussia Dortmund | Bedford, New York | CAM | |
| 2 | Danny Leyva | Seattle Sounders 2 | Burien, Washington | CDM | |
| 3 | Joseph Scally | NYCFC | Lake Grove, New York | RB | |
| 4 | Tyler Freeman | Sporting KC | Shawnee, Kansas | Forward | |
| 5 | Ricardo Pepi | North Texas SC | McKinney, Texas | Forward | |
| 6 | Jonathan Perez | LA Galaxy | Pico Rivera, California | Winger | |
| 7 | Mauricio Cuevas | LA Galaxy | Los Angeles, California | RB | |
| 8 | Griffin Yow | DC United | Clifton, Virginia | Winger | |
| 9 | Dante Sealy | FC Dallas | Frisco, Texas | Winger | |
| 10 | Casey Walls | San Jose Earthquakes | Mill Valley, California | CB | |
| 11 | Julian Grimes | Lonestar SC | Austin, Texas | Forward | |
| 12 | Eric Kinzner | Seattle Sounders | Tacoma, Washington | CB | |
| 13 | Javier Casas | Chicago Fire | Addison, Illinois | CAM | |
| 14 | William Reilly | Atlanta United | Decatur, Georgia | CDM | |
| 15 | Jack McGlynn | BW Gottschee | Middle Village, New York | CM | |
| 16 | Sebastian Burke | Chelsea FC | Raleigh, North Carolina | CAM | |
| 17 | Caden Clark | Barca Academy | Medina, Minnesota | CAM | |
| 18 | Selmir Miscic | Philadelphia Union | Royersford, Pennsylvania | Winger | |
| 19 | Adrian Aguilar | LA Galaxy | Los Angeles, California | CB | |
| 20 | Luc Granitur | Orlando City B | Vero Beach, Florida | Forward | |
| 21 | Tyler Taber | FC Metz | Bertrange, Luxemborg | CM | |
| 22 | Prince Amponsah | NYCFC | Bronx, New York | CB | |
| 23 | Andres Cardenas | Weston FC | Doral, Florida | Forward | |
| 24 | Gavin Krenecki | Sporting KC | Fair Oaks, California | GK | |
| 25 | Jeremy Garay | DC United | Woodbridge, Virginia | CM | |
| 26 | Daniel Edelman | PDA | Warren, New Jersey | CDM | |
| 27 | Elliott Jones | Philadelphia Union | New Britain, Connecticut | GK | |
| 28 | Diego Luna | San Jose Earthquakes | Sunnyvale, California | CM | |
| 29 | Thomas Tulgar | NY Red Bulls | Harrison, New Jersey | Forward | |
| 30 | Benjamin Redzic | FC Dallas | Carrollton, Texas | Forward | |
| 31 | Alex Monis | Chicago Fire | Naperville, Illinois | Winger | |
| 32 | Alex Kenison | San Diego Surf | San Diego, California | CB | |
| 33 | Brooks Thompson | Sporting KC | Floyds Knob, Indiana | GK | |
| 34 | Dante Huckaby | Philadelphia Union | Wayne, Pennsylvania | CB | |
| 35 | Jonathan Gomez | FC Dallas | Keller, Texas | RB | |
| 36 | Wilfredo Rivera | Orlando City | Fleming Island, Florida | Midfield | |
| 37 | Samuel Sarver | Crew SC | Beachwood, Ohio | Forward | |
| 38 | Elton Chifamba | Columbus Crew | Blacklick, Ohio | CDM | |
| 39 | Alec Kenison | San Diego Surf | San Diego, California | Midfield | |
| 40 | Addison Hicks | Seacoast United | Hampton, New Hampshire | Midfield | |
| 41 | Gavin Tabije | RBNY | Matawan, New Jersey | Midfield | |
| 42 | Kobey Stoup | Atlanta United | Montgomery, Alabama | Defender | |
| 43 | Marzuq Puckerin | Boston Bolts | Cambridge, Massachusetts | GK | |
| 44 | Isaac Homer | Portland Timbers | Portland, Oregon | CB | |
| 45 | Paxten Aaronson | Philadellphia Union | Medford, New Jersey | CM | |
| 46 | Anthony Hernandez | Columbus Crew | Reynoldsburg, Ohio | Forward | |
| 47 | Brian Lopez | Weston FC | Miami, Florida | CM | |
| 48 | Brandon Zelaya | De Anza Force | Redwood City, California | Forward | |
| 49 | Sota Kitahara | Seattle Sounders | Edmonds, Washington | CM | |
| 50 | Joey Zalinsky | NY Red Bulls | Brick, New Jersey | RB |
