October 28, 2021 – The Projected Tournament Field, The Seeds, And The Match-Ups Are Based On The Results Of Games Played Through Wednesdary, October 27. The Predictions Are Based On The Most Recent RPI And A Projection Of The Conference Champions Who Will Earn An Automatic Berth Based On Current Standings.
#1 Oregon State Region
First Round: UC Santa Barbara (Big West Automatic) at Saint Louis (Atlantic 10 Automatic)
Second Round: Winner vs. #1 Oregon State (Pac-12 Automatic)
First Round: UCLA (Pac-12 #4) at Denver (Summit Automatic)
Second Round: Winner vs. #16 Grand Canyon (WAC Automatic)
First Round: Santa Clara (WCC Automatic) at Stanford (Pac-12 #3)
Second Round: Winner vs. #8 Pittsburgh (ACC #2)
First Round: Princeton (Ivy Automatic) at St. John’s (Big East #3)
Second Round: Winner vs. #9 Hofstra (CAA Automatic)
#2 Georgetown Region
First Round: Cleveland State (Horizon League Automatic) at West Virginia (MAC #3)
Second Round: Winner vs. #2 Georgetown (Big East Automatic)
First Round: Creighton (Big East #4) at Wake Forest (ACC #8)
Second Round: Winner vs. #15 Missouri State (MVC Automatic)
First Round: Michigan (Big 10 #4) at Bowling Green (MAC #4)
Second Round: Winner at #7 Notre Dame (ACC Automatic)
First Round: Marist (MAAC Automatic) at Maryland (Big Ten #2)
Second Round: Winner vs. #10 Clemson (ACC #3)
#3 Washington Region
First Round: Northern Illinois (MAC Automatic) at Indiana (Big Ten Automatic)
Second Round: Winner vs. #3 Washington (Pac-12 #2)
First Round: Campbell (Big South Automatic) at North Carolina (ACC #6)
Second Round: Winner vs. #14 Akron (MAC #2)
First Round: Portland (WCC #2) at Virginia Tech (ACC#5)
Second Round: Winner vs. #16 Kentucky (CUSA #3)
First Round: UNCG (Southern Conference Automatic) at FIU (CUSA Automatic)
Second Round: Winner vs. #11 Duke (ACC #4)
#4 Marshall Region
First Round: Holy Cross (Patriot Automatic) at Penn State (Big Ten #3)
Second Round: Winner vs. #4 Marshall (CUSA #2)
First Round: Villanova (Big East #5) at Rhode Island (Atlantic 10 #2)
Second Round: Winner vs. #13 New Hampshire (America East Automatic)
First Round: Central Arkansas (Atlantic Sun Automatic) at Louisville (ACC #7)
Second Round: Winner vs. #5 Tulsa (AAC Automatic)
First Round: St. Francis Brooklyn (NEC Automatic) at Cornell (Ivy League #2)
Second Round: Winner vs. #12 Providence (Big East #2)
Last 4 At Large Selections
UCLA
Portland
Villanova
Creighton
Last 4 Out
SMU
Syracuse
Charlotte
Loyola Marymount
Conference Breakdown
| America East | 1 |
| American Athletic | 1 |
| Atlantic Coast | 8 |
| Atlantic Sun | 1 |
| Atlantic 10 | 2 |
| Big East | 5 |
| Big South | 1 |
| Big Ten | 4 |
| Big West | 1 |
| Colonial | 1 |
| Conference USA | 3 |
| Horizon League | 1 |
| Ivy | 2 |
| Metro Atlantic | 1 |
| Mid American | 4 |
| Missouri Valley | 1 |
| Northeast | 1 |
| Pac-12 | 4 |
| Patriot | 1 |
| Southern | 1 |
| Summit | 1 |
| WAC | 1 |
| West Coast | 2 |
| Total | 48 |
16 Seeds
| #1 Oregon State |
| #2 Georgetown |
| #3 Washington |
| #4 Marshall |
| #5 Tulsa |
| #6 Kentucky |
| #7 Notre Dame |
| #8 Pittsburgh |
| #9 Hofstra |
| #10 Clemson |
| #11 Duke |
| #12 Providence |
| #13 New Hampshire |
| #14 Akron |
| #15 Missouri State |
| #16 Grand Canyon |
