October 22, 2021 – The Projected Tournament Field, The Seeds, and the Match-ups Are Based On The Results Of Games Played Through Wednesday, October 20, 2021. The Predictions Are Based On The Most Recent RPI And A Projection Of The Conference Champions Who Will Earn An Automatic Berth Based On Current Standings.
Washington Region
First Round: St. Mary’s (WCC Automatic) at Seattle (WAC #2)
Second Round: Winner at Washington (Pac-12 Automatic)
First Round: LIU (NEC Automatic) at St. John’s (Big East #3)
Second Round: Winner at #16 Hosftra (CAA #2)
First Round: Michigan State (Big Ten #5) at Bowling Green (MAC Automatic)
Second Round: Winner at #8 Pittsburgh (ACC #2)
First Round: Charlotte (CUSA #4) at North Carolina (ACC #7)
Second Round: Winner at #9 FIU (CUSA Automatic)
Georgetown Region
First Round: Princeton (Ivy Automatic) at Maryland (Big Ten #2)
Second Round: Winner at #2 Georgetown (Big East Automatic)
First Round: Holy Cross (Patriot Automatic) at Cornell (Ivy #2)
Second Round: Winner at #15 Providence (Big East #2)
First Round: Central Arkansas (Atlantic Sun Automatic) at Saint Louis (Atlantic 10 Automatic)
Second Round: Winner at #7 Tulsa (AAC Automatic)
First Round: Monmouth (MAAC Automatic) at VCU (Atlantic 10 #2)
Second Round: Winner at #10 Clemson (ACC #3)
Oregon State Region
First Round: James Madison (CAA Automatic) at Duke (ACC #5)
Second Round: Winner at #3 Oregon State (Pac-12 #2)
First Round: Belmont (Southern Conference Automatic) at West Virginia (MAC #3)
Second Round: Winner at #14 Missouri State (MVC Automatic)
First Round: Cleveland State (Horizon League Automatic) at Michigan (Big Ten #4)
Second Round: Winner at #6 Notre Dame (ACC Automatic)
First Round: UCF (AAC #2) at Indiana (Big Ten #3)
Second Round: Winner at #11 Virginia Tech (ACC #4)
Kentucky Region
First Round: Campbell (Big South Automatic) at Wake Forest (ACC #6)
Second Round: Winner at #4 Kentucky (CSUA #2)
First Round: UC Santa Barbara (Big West Automatic) at UCLA (Pac-12 #3)
Second Round: Winner at #13 New Hampshire (America East Automatic)
First Round: Penn State (Big Ten Automatic) at Akron (MAC #2)
Second Round: Winner at #5 Marshall (CUSA #3)
First Round: Denver (Summit Automatic) at Loyola Marymount (WCC #2)
Second Round: Winner at #12 Grand Canyon (WAC Automatic)
Last 4 At Large Selections
Seattle
Michigan State
UCF
Charlotte
Last 4 Out
Louisville
Butler
Rhode Island
San Diego State
Conference Breakdown
| America East | 1 |
| American Athletic | 2 |
| Atlantic Coast | 7 |
| Atlantic Sun | 1 |
| Atlantic 10 | 2 |
| Big East | 3 |
| Big South | 1 |
| Big Ten | 5 |
| Big West | 1 |
| Colonial Athletic | 2 |
| Conference USA | 4 |
| Horizon | 1 |
| Ivy League | 2 |
| Metro Atlantic | 1 |
| Mid American | 3 |
| Missouri Valley | 1 |
| Northeast | 1 |
| Pac-12 | 3 |
| Patriot | 1 |
| Southern | 1 |
| Summit League | 1 |
| WAC | 2 |
| West Coast | 2 |
| Total | 48 |
